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TARGET AUDIENCE

Pathologists

PURPOSE

Soft tissue tumors may sometimes present in superficial locations and pose a diagnostic challenge in classification and distinguishing from other more common cutaneous malignancies.  Conversely, non-mesenchymal tumors may sometimes simulate a soft tissue neoplasm. Recent interesting and challenging cases from the UNMC dermatopathology service will be presented, highlighting diagnostic clues, tips for use of ancillary studies, and relevant updates from the recent pathology literature.

EDUCATIONAL NEED

Pathologists may face diagnostic challenges with difficult or uncommon cases. This lecture will increase the knowledge of learners in identifying soft tissue tumors and delivery methods to improve the quality of care being given to their patients. 

LEARNING OBJECTIVES

List the criteria for diagnosis of dedifferentiated and transdifferentiated melanoma.  Recognize cutaneous clear cell sarcoma features and appropriate utilization of ancillary studies to distinguish from melanoma.  Discuss the clinicopathologic features of mesenchymal tumors with GLI1 gene alterations.  Recognize the features of pseudomyogenic hemangioendothelioma and utilize the appropriate panel of immunohistochemical stains and molecular testing for diagnosis.